The only screw you would be adjusting from the bottom would be the fast idle cam setting. The secondaries have a set screw that is in the throttle plate, but I don't recommend touching that. The mixture screws are on each side of the metering block and of course the idle screw is facing up at an angle and sets the curb idle. I am running a relatively healthy cam and I have it where it idles well at about 850.
Perhaps my irritation is the rich idle.
-Keith
On my small block, I took two 83 Mustang GT Motorcraft/Holley carbs. Converted them to 1850 bowls and used them on my 2x4 Holley set up.
First off they use annular venturis. Second, they are factory calibrated to 14.6 at idle. They came stock with 59 mains. The idle is SO clean stock you can't see any deposits on the plugs AND they are dulling the finish on the ceramic on the headers.
I've been working on these things to FATTEN up the idle to save the headers. You need to work with jetting the idle air bleeds on that. You would be SHOCKED to see how clean the idle is. SHOCKED.
I upped the mains to 64's on the carbs but I think they make as much power with the 59's?
If you are not married to being "correct" I'd recommend ANYONE go this route with a 2x4 Holley set up on the street.
Now a race car is going to be different. You MIGHT even want to reverse the linkage to face the carbs forward with that? Maybe?